motorboat breast cancer

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Motorboat Donations

Donate your old motorboat, save lives, and get a tax reward.

Photo by pasja1000 under Pixabay License

Your ancient motorboat can go a long way in helping save the lives of breast cancer victims in your community. When you donate it to us at Breast Cancer Car Donations , you’ll help increase their odds of beating the devastating disease. At the same time, you’ll reap a ton of amazing rewards, one of which is a handsome tax write-off.

Along with our refutable nonprofit organization partners , we are committed to building better lives for all Americans struggling with the disease. We encourage you to donate your unwanted motorboat and some other vehicles that you would also like to dispose of. We will auction them off and use the collected funds to support the life-saving programs and services being delivered by our charity partners.

The proceeds from your motorboat donation will enable us to support your fellow citizens who are fighting for their lives. Beneficiaries will gain easy access to medical facilities where they can undergo full breast cancer treatment, which includes surgery, chemotherapy, and radiation treatment.

Our nonprofit partners also provide breast cancer survivors with follow-up care such as laboratory work, annual mammograms, and physician visits five years after remission. Other beneficiaries receive free breast cancer screening and prevention and education services.

Our Fast and Painless Donation Process

Who says donating a motorboat has got to be complicated? At Breast Cancer Car Donations, there’s no such thing as complicated!

You can make your motorboat donation in just a few minutes in the comforts of your home. This is basically how it works:

1. Reach out to us.

You can contact us by either calling us at 866-540-5069 or by filling out our online donation form. Provide us a few basic details about your motorboat, including its length, year, and make and model. Tell us when and where you’d want us to pick it up. We’ll then forward the details to an affiliate towing company, which will take care of collecting your boat wherever you’re keeping it .

2. We pick up your motorboat.

The tow truck driver will issue you a towing receipt before picking up and towing your boat. The receipt frees you from any liability pertaining to your donation. It also allows you to cancel your boat’s registration and insurance coverage. As for the cost of the pickup, it’s completely on us!

3. Receive your tax-deductible receipt .

We’ll promptly auction off your motorboat. We’ll try our best to sell it at its highest possible price, so you can get a maximized tax deduction from it. We’ll send you by mail your 100-percent tax-deductible sales receipt two to four weeks following the sale of your motorboat. You can use the receipt to claim your tax deduction when you file your federal tax return in the next tax season.

There you have it! If you’re interested to learn more about our donation program, feel free to visit our FAQs page or call us at 866-540-5069.

Get Ready to Receive These Awesome Perks!

At Breast Cancer Car Donations, recipients and givers alike will benefit from motorboat donations. Here’s a list of the good stuff you’ll get when you donate your motorboat to us:

• Support a meaningful cause that will leave you completely satisfied.
• Dispose of an unwanted boat with zero hassle.
• Take advantage of our free vessel removal service.
• No need to deal with paperwork anymore.
• Avoid the complications and costs of selling an old and damaged watercraft.
• Save money when you stop paying for your boat’s insurance, maintenance, marina, and storage fees.
• Be a local hero in an instant.
• Get the opportunity to collaborate with well-established nonprofits.

What Else Can You Donate?

Another thing you’d love about Breast Cancer Car Donations is the fact that we’re not limited to car and motorboat donations. Offer us an old sedan, a minivan, truck, RV, motorcycle, golf cart, snowmobiles, trailer, and scooter – and we’ll say “yes” without hesitation! Whatever vehicles you’re donating don’t even have to be in good shape – we’ll gladly take them as they are!

For our watercraft donation program, we normally accept sailboats, catamarans, jet skis, yachts, and pontoon boats. Talk to us here if you’re having uncertainties about your vehicle’s eligibility. We’ll let you know right away what we think.

Team Up with Breast Cancer Car Donations Now!

Photo by Courtney Cook under Unsplash License

Touch the hearts of breast cancer patients and their families. Let them know that there is hope with your motorboat donation. Call 866-540-5069 or fill out this donation form to begin.

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Ford Warriors in Pink

Ford Warriors in Pink ® is dedicated to helping those touched by breast cancer, through actions that support, inspire and empower patients, survivors and co-survivors throughout their journey.

Helping Solve Transportation Barriers

Ford Warriors in Pink ® is a Ford Motor Company initiative dedicated to helping and inspiring those in the fight against breast cancer. Ford has been active in the fight against breast cancer for 30 years and has dedicated more than $139 million to the cause. Through the sale of Ford Warriors in Pink inspirational wear and gear, Ford helps provide transportation solutions for patients in need.

BANG THE DRUM LOUDLY. THIS IS WAR.

Since 1993, the Ford Motor Company has been active in the fight against breast cancer. Over a decade ago, Ford increased its efforts with the introduction of Ford Warriors in Pink ® .

Ford Warriors in Pink has since flourished into a long-standing program that helps thousands of patients, survivors and co-survivors affected by the disease each year, with a mission to bring the breast cancer community together and support those who embody courage, commitment and hope in the fight.

By continually asking, “What more can we do?” Ford Warriors in Pink has become an active support system for anyone touched by the disease. And because breast cancer is relentless, Warriors in Pink is relentless — dedicated to fueling the spirit of those living with the disease 365 days a year.

Gear That Gives

Every time you make a purchase of Ford Warriors in Pink ® wear and gear, 100% of Ford profits will be donated to Susan G. Komen ® and Pink Fund ® : two breast cancer organizations that work with Ford Warriors in Pink to help provide transportation solutions for patients in need.

Organizations Supported

Susan G. Komen

Susan G. Komen ® is the world’s leading nonprofit breast cancer organization, funding breast cancer research while providing real-time help to those facing the disease. 100% of Ford profits from the sale of Ford Warriors in Pink ® gear will be donated to support breast cancer patients in need of transportation assistance through the Susan G. Komen Financial Assistance Program .

Pink Fund ® core mission is to mitigate the financial burdens of breast cancer patients in active treatment by providing a bridge between hardship and recovery via direct nonmedical financial assistance, financial navigation, health literacy and education. 100% of Ford profits from the sale of Ford Warriors in Pink ® gear will be donated to help with transportation assistance through grants provided by the Pink Fund financial aid program .

'Motorboating For Breast Cancer' Twits Actually Did Something Amazing And Beautiful With The Money

The definition of motorboating (courtesy of Urban Dictionary) is "The act of pushing one's face in between two ample breasts, and rocking one's head side to side very rapidly while making a vigorous, lip-vibrating "brrr" sound."

So, to recap: when a group of guys who run dating website Simple Pickup - Jason, Jesse and Kong - decided that they would donate $20 to breast cancer for every woman who'd let themselves be motorboated, the money was then kindly but firmly rejected.

In a follow-up video, Jason, Jesse and Kong have clearly not forgiven the 'small group of feminist radicals' who intervened in their money being donated.

But, the story they have to tell about what they did do with the money is incredibly touching once you block out the whining about their money being rejected.

They ended up donating the money to an individual rather than a charity and the recipient was single mother of three kids Crystal Cody, who bursts into tears when they turn up at her house and explain what they'd like to do.

The moment Crystal chats to the boys

Take a look at the video, which places the focus firmly where it should be - on Crystal, and on the issue of breast cancer, and how important it is to get yourself checked out. In the end, they said that it was a "blessing in disguise" the money was turned down because instead, they got to make a personal connection with someone.

If you'd like to donate any money to the cause, the lads have set up a site for Crystal here . Well done boys, you got there in the end.

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Guys Motorboating Random Girls Raises Thousands for Breast Cancer Awareness

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October is Breast Cancer Awareness Month , and there are a lot of organizations getting involved in the fight. But you'll be hard pressed to find a group of people who are having more fun raising money for breast cancer research than these three geniuses. The concept is simple: Motorboating for Breast Cancer Awareness.

These three guys, known on YouTube as ' Simple Pickup ' took to the streets to find women who will let them "motorboat" (a.k.a. stick their face in their cleavage and make a motorboat sound effect). For each motorboat, they donate $20 to the Breast Cancer Research Foundation . On top of that, they are donation an additional $100 for every 100,000 views they get of this video. So even if you don't want to have these dudes slobber on your chest, you can still help their cause!

More From Rock 108

• Patient Care & Health Information
• Diseases & Conditions
• Breast cancer

Breast anatomy

Each breast contains 15 to 20 lobes of glandular tissue, arranged like the petals of a daisy. The lobes are further divided into smaller lobules that produce milk for breastfeeding. Small tubes, called ducts, conduct the milk to a reservoir that lies just beneath your nipple.

Breast cancer is a kind of cancer that begins as a growth of cells in the breast tissue.

After skin cancer, breast cancer is the most common cancer diagnosed in women in the United States. But breast cancer doesn't just happen in women. Everyone is born with some breast tissue, so anyone can get breast cancer.

Breast cancer survival rates have been increasing. And the number of people dying of breast cancer is steadily going down. Much of this is due to the widespread support for breast cancer awareness and funding for research.

Advances in breast cancer screening allow healthcare professionals to diagnose breast cancer earlier. Finding the cancer earlier makes it much more likely that the cancer can be cured. Even when breast cancer can't be cured, many treatments exist to extend life. New discoveries in breast cancer research are helping healthcare professionals choose the most effective treatment plans.

Breast cancer care at Mayo Clinic

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• A Book: Beyond Breast Cancer
• Angiosarcoma
• Ductal carcinoma in situ (DCIS)
• Inflammatory breast cancer
• Invasive lobular carcinoma
• Lobular carcinoma in situ (LCIS)
• Male breast cancer
• Paget's disease of the breast
• Recurrent breast cancer

• Nipple changes

Breast and nipple changes can be a sign of breast cancer. Make an appointment with a healthcare professional if you notice any changes.

Signs and symptoms of breast cancer may include:

• A breast lump or thickened area of skin that feels different from the surrounding tissue.
• A nipple that looks flattened or turns inward.
• Changes in the color of the breast skin. In people with white skin, the breast skin may look pink or red. In people with brown and Black skin, the breast skin may look darker than the other skin on the chest or it may look red or purple.
• Change in the size, shape or appearance of a breast.
• Changes to the skin over the breast, such as skin that looks dimpled or looks like an orange peel.
• Peeling, scaling, crusting or flaking of the skin on the breast.

When to see a doctor

If you find a lump or other change in your breast, make an appointment with a doctor or other healthcare professional. Don't wait for your next mammogram to see if the change you found is breast cancer. Report any changes in your breasts even if a recent mammogram showed there was no breast cancer.

The exact cause of most breast cancers isn't known. Researchers have found things that increase the risk of breast cancer. These include hormones, lifestyle choices and things in the environment. But it's not clear why some people who don't have any factors get cancer, yet others with risk factors never do. It's likely that breast cancer happens through a complex interaction of your genetic makeup and the world around you.

Healthcare professionals know that breast cancer starts when something changes the DNA inside cells in the breast tissue. A cell's DNA holds the instructions that tell a cell what to do. In healthy cells, the DNA gives instructions to grow and multiply at a set rate. The instructions tell the cells to die at a set time. In cancer cells, the DNA changes give different instructions. The changes tell the cancer cells to make many more cells quickly. Cancer cells can keep living when healthy cells would die. This causes too many cells.

The cancer cells might form a mass called a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, cancer cells can break away and spread to other parts of the body. When cancer spreads, it's called metastatic cancer.

The DNA changes that lead to breast cancer most often happen in the cells that line the milk ducts. These ducts are tubes designed to carry milk to the nipple. Breast cancer that starts in the ducts is called invasive ductal carcinoma. Breast cancer also can start in cells in the milk glands. These glands, called lobules, are designed to make breast milk. Cancer that happens in the lobules is called invasive lobular carcinoma. Other cells in the breast can become cancer cells, though this isn't common.

Risk factors

Factors that may increase the risk of breast cancer include:

• A family history of breast cancer. If a parent, sibling or child had breast cancer, your risk of breast cancer is increased. The risk is higher if your family has a history of getting breast cancer at a young age. The risk also is higher if you have multiple family members with breast cancer. Still, most people diagnosed with breast cancer don't have a family history of the disease.
• A personal history of breast cancer. If you've had cancer in one breast, you have an increased risk of getting cancer in the other breast.
• A personal history of breast conditions. Certain breast conditions are markers for a higher risk of breast cancer. These conditions include lobular carcinoma in situ, also called LCIS, and atypical hyperplasia of the breast. If you've had a breast biopsy that found one of these conditions, you have an increased risk of breast cancer.
• Beginning your period at a younger age. Beginning your period before age 12 increases your risk of breast cancer.
• Beginning menopause at an older age. Beginning menopause after age 55 increases the risk of breast cancer.
• Being female. Women are much more likely than men are to get breast cancer. Everyone is born with some breast tissue, so anyone can get breast cancer.
• Dense breast tissue. Breast tissue is made up of fatty tissue and dense tissue. Dense tissue is made of milk glands, milk ducts and fibrous tissue. If you have dense breasts, you have more dense tissue than fatty tissue in your breasts. Having dense breasts can make it harder to detect breast cancer on a mammogram. If a mammogram showed that you have dense breasts, your risk of breast cancer is increased. Talk with your healthcare team about other tests you might have in addition to mammograms to look for breast cancer.
• Drinking alcohol. Drinking alcohol increases the risk of breast cancer.
• Having your first child at an older age. Giving birth to your first child after age 30 may increase the risk of breast cancer.
• Having never been pregnant. Having been pregnant one or more times lowers the risk of breast cancer. Never having been pregnant increases the risk.
• Increasing age. The risk of breast cancer goes up as you get older.
• Inherited DNA changes that increase cancer risk. Certain DNA changes that increase the risk of breast cancer can be passed from parents to children. The most well-known changes are called BRCA1 and BRCA2. These changes can greatly increase your risk of breast cancer and other cancers, but not everyone with these DNA changes gets cancer.
• Menopausal hormone therapy. Taking certain hormone therapy medicines to control the symptoms of menopause may increase the risk of breast cancer. The risk is linked to hormone therapy medicines that combine estrogen and progesterone. The risk goes down when you stop taking these medicines.
• Obesity. People with obesity have an increased risk of breast cancer.
• Radiation exposure. If you received radiation treatments to your chest as a child or young adult, your risk of breast cancer is higher.

Things you can do to lower your risk of breast cancer

Breast self-exam

To perform a breast self-exam for breast awareness, use a methodical approach that ensures you cover your entire breast. For instance, imagine that your breasts are divided into equal wedges, like pieces of a pie, and sweep your fingers along each piece in toward your nipple.

Making changes in your daily life may help lower your risk of breast cancer. Try to:

• Ask about breast cancer screening. Talk with your doctor or other healthcare professional about when to begin breast cancer screening. Ask about the benefits and risks of screening. Together, you can decide what breast cancer screening tests are right for you.

Become familiar with your breasts through breast self-exam for breast awareness. You may choose to become familiar with your breasts by occasionally inspecting them during a breast self-exam for breast awareness. If there is a new change, a lump or something not typical in your breasts, report it to a healthcare professional right away.

Breast awareness can't prevent breast cancer. But it may help you to better understand the look and feel of your breasts. This might make it more likely that you'll notice if something changes.

• Drink alcohol in moderation, if at all. Limit the amount of alcohol you drink to no more than one drink a day, if you choose to drink. For breast cancer prevention, there is no safe amount of alcohol. So if you're very concerned about your breast cancer risk, you may choose to not drink alcohol.
• Exercise most days of the week. Aim for at least 30 minutes of exercise on most days of the week. If you haven't been active lately, ask a healthcare professional whether it's OK and start slowly.

Limit menopausal hormone therapy. Combination hormone therapy may increase the risk of breast cancer. Talk with a healthcare professional about the benefits and risks of hormone therapy.

Some people have symptoms during menopause that cause discomfort. These people may decide that the risks of hormone therapy are acceptable in order to get relief. To reduce the risk of breast cancer, use the lowest dose of hormone therapy possible for the shortest amount of time.

• Maintain a healthy weight. If your weight is healthy, work to maintain that weight. If you need to lose weight, ask a healthcare professional about healthy ways to lower your weight. Eat fewer calories and slowly increase the amount of exercise.

Medicines and operations for those a high risk of breast cancer

If you have a high risk of breast cancer, you might consider other options to lower the risk. You might have a high risk if you have a family history of breast cancer. Your risk also might be higher if you have a history of precancerous cells in the breast tissue. Talk about your risk with your healthcare team. Your team might have options for lowering your risk, such as:

Preventive medicines. Using estrogen-blocking medicines can lower the risk of breast cancer in those who have a high risk. Options include medicines called selective estrogen receptor modulators and aromatase inhibitors. These medicines also are used as hormone therapy treatment for breast cancer.

These medicines carry a risk of side effects. For this reason, they're only used in those who have a very high risk of breast cancer. Discuss the benefits and risks with your healthcare team.

• Preventive surgery. If you have a very high risk of breast cancer, you may consider having surgery to lower the risk of breast cancer. One option might be surgery to remove the breasts, called prophylactic mastectomy. Another option is surgery to remove the ovaries, called prophylactic oophorectomy. This operation lowers the risk of breast cancer and ovarian cancer.

More Information

• Breast cancer chemoprevention
• Genetic testing for breast cancer: Psychological and social impact

Living with breast cancer?

Connect with others like you for support and answers to your questions in the Breast Cancer support group on Mayo Clinic Connect, a patient community.

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• Cancer facts and figures 2023. American Cancer Society. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2023-cancer-facts-figures.html. Accessed Aug. 9, 2023.
• Abraham J, et al., eds. Breast cancer. In: The Bethesda Handbook of Clinical Oncology. 6th ed. Kindle edition. Wolters Kluwer; 2023. Accessed March 30, 2023.
• Breast cancer. Cancer.Net. https://www.cancer.net/cancer-types/breast-cancer/view-all. Accessed Aug. 2, 2023.
• Mukwende M, et al. Erythema. In: Mind the Gap: A Handbook of Clinical Signs in Black and Brown Skin. St. George's University of London; 2020. https://www.blackandbrownskin.co.uk/mindthegap. Accessed Aug. 10, 2023.
• Townsend CM Jr, et al. Diseases of the breast. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 21st ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Aug. 2, 2023.
• Breast cancer risk reduction. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=2&id=1420. Accessed Aug. 2, 2023.
• Breast cancer prevention (PDQ) – Patient version. National Cancer Institute. https://www.cancer.gov/types/breast/patient/breast-prevention-pdq. Accessed Aug. 2, 2023.
• Breast cancer. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1419. Accessed Aug. 2, 2023.
• Klimberg VS, et al., eds. Breast cancer diagnosis and techniques for biopsy. In: Bland and Copeland's The Breast: Comprehensive Management of Benign and Malignant Diseases. 6th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Aug. 2, 2023.
• Palliative care. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=3&id=1454. Accessed Aug. 2, 2023.
• Cancer-related fatigue. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=3&id=1424. Accessed Aug. 2, 2023.
• Breast SPOREs. National Cancer Institute. https://trp.cancer.gov/spores/breast.htm. Accessed Aug. 9, 2023.
• Ami TR. Allscripts EPSi. Mayo Clinic. Jan. 31, 2023.
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• Member institutions. Alliance for Clinical Trials in Oncology. https://www.allianceforclinicaltrialsinoncology.org/main/public/standard.xhtml?path=%2FPublic%2FInstitutions. Accessed Aug. 9, 2023.
• Giridhar KV (expert opinion). Mayo Clinic. Oct. 18, 2023.
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Associated Procedures

• 3D mammogram
• Brachytherapy
• BRCA gene test
• Breast cancer risk assessment
• Breast cancer supportive therapy and survivorship
• Breast cancer surgery
• Breast self-exam for breast awareness
• Chemotherapy
• Chemotherapy for breast cancer
• Chest X-rays
• Complete blood count (CBC)
• Hormone therapy for breast cancer
• Molecular breast imaging
• Positron emission tomography scan
• Precision medicine for breast cancer
• Radiation therapy
• Radiation therapy for breast cancer
• Sentinel node biopsy

News from Mayo Clinic

• Mayo Clinic Minute: Treating breast cancer through surgery May 09, 2024, 03:45 p.m. CDT
• New study finds triple-negative breast cancer tumors with an increase in immune cells have lower risk of recurrence after surgery April 02, 2024, 04:31 p.m. CDT
• Understanding triple-negative breast cancer and its treatment Jan. 04, 2024, 04:00 p.m. CDT
• Mayo Clinic's DNA study reveals BRCA1 mutations in 3 sisters, prompts life-changing decisions Nov. 04, 2023, 11:00 a.m. CDT
• Beyond BRCA1/2: Pinpointing the risk of inherited breast cancer genes Oct. 28, 2023, 11:00 a.m. CDT
• 17-gene signature linked to remission after triple-negative breast cancer treatment  Oct. 21, 2023, 11:00 a.m. CDT
• Mayo Clinic Minute: Does soy increase breast cancer risk? Oct. 17, 2023, 06:30 p.m. CDT
• Mayo Clinic Minute: The importance of supplemental screenings for dense breasts Sept. 26, 2023, 02:28 p.m. CDT
• Mayo Clinic Minute: Why Black women should consider screening for breast cancer earlier June 15, 2023, 04:30 p.m. CDT
• Mayo Clinic Minute: Why some patients with breast tumors could possibly avoid a mastectomy April 18, 2023, 01:30 p.m. CDT
• Patients with multiple tumors in one breast may not need mastectomy, research finds March 28, 2023, 09:00 p.m. CDT
• Mayo Clinic researchers identify women with twice the risk of cancer in both breasts Jan. 19, 2023, 02:58 p.m. CDT
• Short journey for quicker breast cancer care Nov. 17, 2022, 12:00 p.m. CDT
• Mayo Clinic Minute: Why people with breast cancer should ask their health care team about clinical trials Oct. 21, 2022, 04:00 p.m. CDT
• Mayo Clinic receives National Cancer Institute grant for breast cancer research Oct. 20, 2022, 06:47 p.m. CDT
• Mayo Clinic Minute: Determining if you have dense breasts Oct. 13, 2022, 02:05 p.m. CDT
• Mayo Clinic Q&A podcast: Surgical options for breast cancer treatment Oct. 04, 2022, 01:00 p.m. CDT
• Science Saturday: The Living Breast Biobank July 30, 2022, 11:00 a.m. CDT
• Collaborative care, individualized therapy allows patient to celebrate despite cancer diagnosis July 01, 2022, 05:00 p.m. CDT
• Mayo Clinic, Médica Sur expand relationship to advance cancer care June 21, 2022, 09:00 p.m. CDT
• Mayo Clinic Q&A podcast: What to expect after breast cancer June 21, 2022, 12:42 p.m. CDT
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Alternative forms

motor +‎ boat

Pronunciation

• ( UK ) IPA ( key ) : /ˈməʊtəˌbəʊt/
• ( US ) IPA ( key ) : /ˈmoʊtəˌboʊt/

motorboat ( plural motorboats )

• ( nautical ) Any vessel driven by an engine (either inboard or outboard ), but especially a small one.

Translations

motorboat ( third-person singular simple present motorboats , present participle motorboating , simple past and past participle motorboated )

• To ride in a motorboat.
• 2011 October 10, Molly McCarthy, Stella Blake-Kelly, Peter McCaffrey, “Year In News”, in Salient , Victoria University of Wellington, page 9 : ACT on Campus President Peter McCaffrey allegedly motorboated Heather Roy at the ACT Party offices over the newly-passed piece of legislation.
• 2012 June 8, “ Underwood takes her 3rd video of year win at CMTs ”, in Bali Post , page 12 : Kellie Pickler pretended to motorboat an imaginary pair of breasts to introduce Little Big Town's performance of “Pontoon,” [ … ]
• 2013 October 25, “Breast cancer awareness gone too far”, in The Daily Athenaeum , West Virginia University, page 4 : Other promotional events, such as “No Bra” day or the “ motorboating girls for breast cancer awareness” campaign, also take things a little too far.
• 2013 , "19 Most Lustable Celebs", VIBE , April/May 2013, page 84 : You're blind to the blue Pacific water and glaring sun as your entire face is buried in Sofia's bosom—you're motorboating on a motorboat!
• 2014 , Madison Holmes, "Big boobs: The bane of my existence", The Orion (Chico State University), 15 October 2014, page A6 : While talking to some dude at a party, he bent over and motorboated me.
• 2015 , Jill Sorenson, Shooting Dirty , unnumbered page : Tiffany put her hands on Janelle's hips and motorboated her breasts.
• 2016 July 19, Shane Allison, You're the One I Want: A Novel , Simon and Schuster, →ISBN : Tangela has these huge titties, the kind I like to motorboat .
• 2013 August 1, Ben Brooks, Lolito , Canongate Books, →ISBN : 'And we can fucking smash his dick in. Elliot's coming. And Hattie.' 'Are you lying?' 'I am not lying.' 'If you are lying, I am going to smash your dick in.' ... Amundsen pushes his whole head into the bowl, motorboating his food.
• 2021 April 6, Natasha Osiris, Transformed into a Ts-Girl (M2F) by a Dice , AuthorHouse, →ISBN : Immediately I started to lick, to suck, to kiss, to blow and to motorboat her pussy .
• 2012 07 , Karen Alterisio Nelson, Millions of Reasons to Lie , iUniverse, →ISBN , page 118 : She wanted to straddle him and motorboat him right there. She thought about his chest again, and his lips. His dark eyelashes made his dark chocolate eyes so much darker, especially when they softened with desire.
• 2017 April 9, Harvey C Gordon, SEXciting PUNography , eBook Partnership, →ISBN : A man who was having trouble recalling an important piece of information put his head between his girlfriend's breasts and had her motorboat him. You might say the man was racking his brain trying to remember.
• 2019 April 24, Cassandra Dee, Buy Me: A Forbidden Romance , Cassandra Dee Romance: Some guys would have welcomed the opportunity to motorboat his face between two huge bags of saline, enjoying the artificial bounceback.
• 2020 January 28, Joe Ide, Hi Five , Mulholland Books, →ISBN : “Why didn't you just take your tits out and motorboat him?” “He was nice and polite, okay?” she said. “Something you should learn about. Where's the fucking car?” As good a time as any, Isaiah thought.
• 2020 August 18, Ashley & JaQuavis, Money Devils 1: A Cartel Novel , St. Martin's Press, →ISBN : It was the same girl from the boat earlier that day, but she was the one driving this go-around. She motorboated his face as he licked away. A petite-framed Latina woman was giving him oral while massaging his sack.
• 2021 September 1, Goran Radanovic, 10 Erotic Short Stories Vol. 1 , Goran Radanovic, →ISBN , page 51 : He smiled as I motorboated his face between my breasts.
• For more quotations using this term, see Citations:motorboat .

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• J Family Med Prim Care
• v.11(8); 2022 Aug

A review of the neurological complications of breast cancer

Yasaman hekmatnia.

1 Department of Neurology, Islamic Azad University of Medical Sciences, Sari, Mazandaran, Iran

Nima Movahednia

2 Islamic Azad University of Medical Sciences, Mashhad, Iran

Negin Hajhamidiasl

3 Ilam University of Medical Sciences, Ilam, Iran

Elnaz Hekmat

4 Medical Doctor, Fasa University of Medical Sciences, Fasa, Iran

Aida Hekmat

Sara khademi.

5 Shiraz University of medical sciences, Shiraz, Iran

Conducting broad assessments of the main burden of breast cancer is the core factor for improving overdiagnosis and overtreatment of breast cancer patients as well as their survival rates. Breast cancer patients may experience neurological complications that cause devastating effects on them. Chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are two of the most reported complications. Objective: This study aims to review the neurological complications of breast cancer and the ways to control and treat them. Comprehensive searches were carried out about the keywords of Breast Cancer, Neurological Complications, and Breast Cancer Consequences. These keywords were searched through the most well-known databases of MEDLINE, PUBMED, Cochrane Library, Best Evidence, CancerLit, HealthSTAR, and LegalTrac. In this regard, 83 articles were chosen to be included in this study from 2010 to 2021. The identification and treatment process of neurologic syndromes are not easy. The main neurologic syndromes which the breast cancer patients face are opsoclonus myoclonus syndrome (OMS), encephalitis, sensorimotor neuropathy, retinopathy, cerebellar degeneration, and stiff-person’s syndrome. CIPN and neuropathic pain are among the most prevalent side effects which are categorized as neurological complications and mainly seen 1 year after the management of breast cancer. Aiming to minimize the burden following the treatment of breast cancer, these complications should be diagnosed and treated accurately.

Introduction

One of the most prevalent tumors that could cause numerous deaths among women in the world is breast cancer. Based on the data achieved from the World Health Organization in 2021, about 12% of the annual newly detected cancer cases in the world are of breast cancer.[ 1 ] An early diagnosis of breast cancer makes the possibility of improving the survival rate to 80%. In this regard, providing screening programs for the management of breast cancer patients remains a crucial need that highlights the requirement for an intensive evaluation of the burden of breast cancer. So, having the knowledge of the management and side effects of cancer and its effect on the nervous system through metastatic disease is very important. Some of the main side effects of the management of breast cancer are neuropathic pain (NP), CIPN, immune system weakness, coagulation disorders, or paraneoplastic syndromes, which all could cause cerebrovascular disease.[ 2 , 3 ]

The most prevalent neurological complications following the treatment of breast cancer include NP, CIPN, cognitive impairment, stroke, and encephalopathy. CIPN and NP complications may be more disabling than the cancer itself.[ 4 ] Many chemotherapeutic agents could cause CIPN that may lead to discontinuation of treatment or/and dose reduction.[ 5 ] Despite the role of the chemotherapy regimen on the incidence of CIPN, alcohol consumption and diabetes could affect it simultaneously.[ 6 ] In more than 33% of younger breast cancer patients, chronic NP may happen after the treatment.[ 7 ]

The burden of NP and CIPN complications in women with breast cancer and their etiology, frequency, and impact on the life quality of the patients are still poorly understood. Conducting prospective studies provides a deep understanding and characterization of these complications, and makes the possibility of creating a more accurate description of the burden of breast cancer in various settings. Additionally, it could develop adequate strategies for minimizing the adverse effects of these complications during treatment.[ 8 , 9 ]

Following the studies carried out in this regard, it was cleared that there was no specific comprehensive study in terms of the neurological complications caused by the treatment of breast cancer.[ 10 ] Therefore, the present study aimed to assess the incidence rate of the neurological complications following breast cancer and providing suitable recommendations for the management of breast cancer patients and guidelines for future research.

Standardized methods of Cochrane Collaboration[ 11 ] adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) were performed. In this regard, all related databases of EMBASE, MEDLINE, Scopus, PubMed, PubMed Central, and Clinical Trials databases were searched. All the searched articles were in English and from 2010 to 2021. At first, 271 articles were searched based on the keywords of Breast Cancer, Epidemiology, Nervous System Diseases, and Cognition Disorders. All the searched titles were classified into four categories of highly related titles, less related titles, similar titles, and not related titles. Therefore, 168 articles were deleted due to similarity in subject and content, 15 and 9 articles were deleted due to some specific reasons, and dissimilarity in title and content, respectively. After the final screening, 83 articles were selected to be included in the main criteria of the present study and reviewed fully. The schematic process of all the steps of the method of the present study is shown in [ Figure 1 ].

The selection process of the articles in the present study is based on the PRISMA method

Etiology of breast cancer

Breast cancer is a multifactorial, heterogeneous, and complex disease. Despite the effect of some specific genetic factors such as mutations of BRCA1 and RCA2 genes in breast cancer, most breast cancer patients do not present a specific evident risk profile.[ 12 , 13 ] However, the mutations in the inherited high-penetrance genes are responsible for about 5–10% of all breast cancer cases.[ 14 ]

Some specific factors could result in breast cancer which include age, the personal or family history of breast cancer, hormone replacement therapy (HRT), physical inactivity, alcohol consumption, genetic predisposition, exposure to ionizing radiation, reproductive and hormonal factors, and obesity[ 15 , 16 ] Various factors may lead to breast cancer that are briefly mentioned in Table 1 .

The main destructive factors of breast cancer derived in accordance with[ 17 ]

BC: Breast Cancer

Diagnosis and staging

At first, breast cancer not only appears as a mammographic abnormality or palpable mass, but it can be detected through breast pain, breast skin change, and nipple discharge. In this regard, all the suspicious mammographic and palpable breast lesions should go under biopsy. More than two-thirds of the breast masses, particularly among young premenopausal women, are not malignant and about 15–25% of them remain in situ .[ 36 ] Abnormal cells of carcinoma in situ (CIS) are specified through the proliferation of malignant cells in the lobules or ducts of the breast without interstitial invasion of hepatocellular carcinomas (HCC). Lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) are two of the major subtypes of breast cancer. The earlier form of breast cancer is considered to be DCIS that is not invasive with a low risk of becoming invasive.[ 37 , 38 ]

Unlike DCIS, LCIS is microscopic and does not have any clinical and mammographic signs and is more likely to have bilateral involvement. These abnormal cells inside the milk duct are grouped in small, solid masses with a uniform, small, and round-to-oval nucleus.[ 39 ] Breast cancers can be classified by a scheme that consists of all the properties of the tumor that clarifies its life history. As per the American Joint Committee on Cancer (AJCC), TNM Classification of Malignant Tumors (TNM) is mainly based on the assumption that cancers of the same histology and anatomic site have similar patterns of extension and growth. In this classification system, T is representative of the size of the primary tumor, N is representative of the regional lymph node involvement, and M of the distant metastasis [ Table 2 ].[ 40 ] At the time of clinical evaluation, a combination of the T, N, and M classification shows the extent of the disease.

Staging breast cancers based on the TNM system. Derived as per Kalli et al .[ 41 ]

T: Tumor size (largest diameter). N: Nodal involvement (nodal status). M: Metastases

The system of stage grouping is applied for the aim of analysis and tabulation [ Table 3 ]. The adoption of this grouping system is for ensuring that each group is more or less homogeneous for survival, and ensuring that the rate of each group is distinctive.[ 42 ]

Staging system of breast cancer with an adaptation of the TNM system[ 42 ]

1 T1 includes T1MIC. 2 The prognosis of the patients with pN0 is like those with pN1

Breast Cancer Metastases to the Neurocranium

Skull metastases.

In patients with breast cancer, the rate of hematogenous skull metastases is higher in comparison with any other tumors.[ 42 ] As reported by Othman et al. ,[ 43 ] in the early stage of the disease, in about half of the breast cancer patients, bone metastases can be detected by 99 mTc scintigraphy. Anyway, many of these lesions do not become symptomatic and it could be estimated that these lesions allow the other complications to slowly develop breast cancer. Local pain can be seen in patients with local swelling and at the time of presentation, neurologic deficits are not frequent. When the bone metastases reach a specific size and become symptomatic, they can be diagnosed. Metastases to the calvarial bones can be noted by the patients themselves as swelling.[ 44 ] When the orbit is involved, metastasis to the skull base may become symptomatic by exophthalmia or/and diplopia. In this regard, for the visualization of the bone destruction extent, a CT scan is needed. For the detection of the infiltration of the neural tissue and dura, MRI is superior to CT. Therefore, both imaging techniques are demanded preoperatively. Surgical operation should be considered in the following situations; when a massive destruction of dura and adjacent bone happen, after a neurological deficit due to solitary metastasis, and when patients are detected with painful tumors.[ 45 , 46 ] The purpose of surgery is for resection of the infiltrated bone in a cranioplasty operation and its replacement with bone-cement or a titan mesh. This operation is beneficial, especially in complex lesions that involve the cranial base. When metastases involved the dura, it should be resected and then replaced. The differential diagnosis of the skull includes benign tumor-like lesions (eosinophilic granuloma, hyperostosis, and fibrous dysplasia) and primary skull tumors (chordoma, chondrosarcoma, osteoma, epidermoid, and dermoid cysts).[ 47 ]

Dural metastases

Dural metastases are rare and can be found at autopsy in just about 10% of the patients with advanced systemic cancers. In their study, Chan et al .[ 48 ] introduced breast cancer as the second most common malignancy that could cause dural metastases. Dural metastases may appear as the metastatic subdural fluid collection or solid masses that assemble a chronic subdural hematoma (SDH). One of the main differential diagnoses of meningioma tumors is dural metastases and should be suspected in patients who are detected with an underlying malignant disease and a chronic SDH.[ 49 ] After removing the solid dural metastases, the dura is incised around the lesion circumferentially. Then, the tissue of the brain and the tumor are dissected from each other with cottonoids and gentle coagulation while avoiding retraction of the brain and preserving the accompanying veins. The tumor can be removed gently after circumferential dissection. Autologous transplantation or an artificial material should be used for performing dura substitute procedure. The intraoperative aspects of both systemic meningioma metastases and dural metastases are similar. However, for clarifying the diagnosis, it is essential to conduct a histological examination.[ 50 ]

Paraneoplastic syndromes

As a rare disorder following cancer, paraneoplastic neurological syndromes (PNS) affect less than 1% of breast cancer patients.[ 51 ] PNS disorders following breast cancer mainly include brainstem encephalitis, myelopathy, stiff person syndrome, sensory neuropathy, cerebellar degeneration, opsoclonus myoclonus, and encephalomyelitis.[ 52 ] The most prevalent PNS disorder following breast cancer is subacute cerebellar degeneration. Another group of rare disorders of the paraneoplastic syndromes could occur following breast cancer like retinopathy. Some systemic symptoms such as fatigue, fever, anorexia, and weight loss may also be observed.[ 53 ] The best classical onconeural antibodies that are associated with PNS and breast cancer include anti-Ma2 (anti-Ta) associated with cerebellar degeneration, brainstem encephalitis, and limbic encephalitis; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) associated with limbic encephalitis; Purkinje cell cytoplasmic antibody type 1 (PCA1) associated with paraneoplastic cerebellar degeneration (PCD); type II anti-neuronal nuclear antibody (ANNA-2) associated with opsoclonus myoclonus and brainstem encephalitis; and amphiphysin protein associated with sensory neuropathy, encephalomyelitis, myoclonus, myelopathy, and stiff person syndrome.[ 54 , 55 ]

In more than four-fifths of the cancer patients, PNS precedes the diagnosis of cancer by several months to years [183, 189]. Nearly, in all the cases, after the diagnosis of PNS, an underlying cancer could be identified within 5 months. Additionally, after 2 years, the risk of coexistent cancer will decrease and after 4 years, it is considered highly unlikely.[ 56 ] In PNS patients when there is a breast cancer, a combination of mammography and clinical examination followed by whole-body 18F-fluorodeoxyglucose-positron emission tomography/Computerized Tomography (FDG-PET/CT) (18F-FDG PET/CT) screening and breast MRI should be carried out in all the cases with negative initial screening.[ 52 ] If the initial screening is negative, repeat assessments should be performed every 6 months for at least 2 years.[ 54 ]

Because of the heterogeneity in the symptomatology and timing, and the presence of onconeural antibodies, the accurate diagnosis of the paraneoplastic syndrome is challenging. For instance, only in 60–70% of the paraneoplastic syndrome patients with breast cancer, antibodies could be found. Consequently, when the result antibodies tests is positive, it could be productive, otherwise the results of test could not be used effectively in diagnosis of paraneoplastic neurologic syndrome. Aiming to solve this challenge and the diagnosis of paraneoplastic neurological disorders, four components are defined by the international panel of neurologists[ 57 , 58 ]:

• Existence of any trace of neurological symptoms
• Existence of any signs of cancer within 4 years from the initial observation of the neurological manifestations
• Exclusion of other neurological disorders
• Existence of one of the following: the presence of inflammation with negative cytology in the cerebrospinal fluid (CSF) analysis, presence of a lesion in the temporal lobe in the brain MRI imaging, and seeing epileptic activity within the temporal lobe through the electroencephalogram (EEG) test.[ 59 , 60 ]

Neurologic complications of cancer

PNS and the central nervous system (CNS) are very susceptible to various types of cancer and their treatments. The development of the primary spinal cord and brain tumors is responsible for the most direct involvement of the nervous system. In many types of cancers, metastasis can be seen toward the CNS, and brain metastases are of the most prevalent problems caused by malignancies like breast cancer.[ 61 ] These metastases may involve the parenchyma of the spine or brain or their subarachnoid space. When PNS is involved, the spread of cancer happens through direct infiltration of the muscle, plexi, and nerve roots by the surrounding malignancies. Sometimes, the body’s nervous system may get affected by cancer in a sudden and devastating way that includes transection of the cord or compression of the epidural spinal cord caused by pathologic fractures of the bones of the spine involved by cancer; a sudden uncontrolled seizure activity caused by brain tumors that lasts for at least 5 min; and intracranial pressure (ICP) associated with the growth of the mass lesion and edema.[ 62 , 63 ]

PNS are the most well-known remote or indirect effects of cancer on the nervous system. The hypercoagulable state could result from cancer that causes cerebrovascular complications. It should be noted that conducting therapeutic options for the treatment of cancer could cause neurologic complications. Radiation-induced injury to the peripheral nerves, spine, and brain, and CIPN are the most prevalent complications following the treatment of cancer. Infectious complications in the nervous system ca result from the suppressant effect of cancer and its treatment on the body’s immune system.[ 64 ] Both direct and indirect complications of cancer are mentioned in Table 4 .

Neurological complications of breast cancer

In the first year following the treatment of breast cancer, nearly half of patients experience at least one neuro-oncological complication. Cognitive impairment, CIPN, and NP are among the most prevalent complications experienced by one-tenth of the patients.[ 74 ]

Both direct and indirect neurological complications include side effects of treatments, paraneoplastic syndromes, or/and vascular disorders and maybe the main source of illness among breast cancer patients.[ 75 ] Pereira et al .[ 76 ] revealed that about 50% of the women with breast cancer, who underwent treatment, experienced at least one neurooncological complication and 25% experienced two complications. In their study, the most prevalent complications were CIPN and NP.

Due to the possibility of cancer recurrence and exposure of patients to further treatments, various adverse effects of applying the treatment options for the management of cancer patients, and providing the potential of recovering the patients from some of the neurooncological complications, comprehensive evaluations of the prevalence of these complications should be carried out in long-term follow-up conditions.[ 76 ]

Paraneoplastic neuropathy

The earliest reported paraneoplastic sensorimotor neuropathy as a complication following breast cancer was reported in 1994. In their study, Chernyshkova et al .[ 77 ] stated that patients with breast cancer experienced radicular symptoms, numbness, paresthesia, muscle cramps, and neurological manifestations of the lower and upper muscle weakness. They reported that these neurological manifestations were experienced by the patients for up to 8 years before the breast cancer discovery. Breast cancer patients may present with various localized tumors in their chest and armpit lymph nodes, and stage IV tumors. After breast cancer, neurological manifestations may develop to chronic, while disability may not develop to upper levels.[ 77 ] Various studies reported that the neurological manifestations of the paraneoplastic syndrome could be relieved by conducting a plasmapheresis process.[ 78 , 79 ]

The rare syndrome of autoimmune paraneoplastic autonomic neuropathy in patients with breast cancer may be experienced with degenerative ataxia on the left and numbness in all extremities. In these situations, the presence of anti-neuronal antibodies can be detected through sural nerve biopsy and serum analysis.[ 80 ]

Sensorimotor polyneuropathy is a systemic process during which the nerve cells are damaged and may be observed in patients with breast cancer.[ 81 ] Criscitiello et al [ 82 ] reported that breast cancer patients who are detected with motor neuron disorders (MNDs) could be treated effectively by anastrozole, capecitabine, and docetaxel.

Anyway, the paraneoplastic neurological manifestation may be different in each breast cancer patient. For instance, some patients may experience rapidly progressive course that is mainly because of anti-Hu (ANNA-1) antibodies, while others without these antibodies will not face such a rapid progress in lower motor neuron signs, and prolonged courses. However, there is diversity in seropositivity and presentation in paraneoplastic neurological manifestation that should be considered for planning an appropriate treatment strategy.[ 83 ]

Cancer can affect the nervous system directly or indirectly through the side effects of drug therapy. One of the most destructive adverse effects is on the immune system that causes paraneoplastic syndromes. The application of immunosuppressive drugs for the management of cancer may affect the CNS by opportunistic infections. Neurological complications such as NP and CIPN are among the most prevalent side effects of breast cancer management during the first year after diagnosis. These complications can be present even 3 years of the diagnosis of cancer. Swift and accurate diagnosis of these complications is a critical step in decision-making about choosing an appropriate treatment option in the management process of patients with breast cancer.

One important factor that should be considered is testing the breast cancer patients for anti-neuronal antibodies due to their role in the neurologic manifestations in any neurological disorders. These antibodies could improve the accuracy of the diagnosis even up to 100%. One of the main effective mechanisms against malignancy is manipulating the immune system by conducting appropriate treatment options for improving the survival rate of the patients. In this regard, it is recommended to conduct various clinical trials to investigate the effectiveness of different therapeutic options for decreasing the possibility of neurological complications in association with breast cancer. Due to the rarity of some of these syndromes, more than two-thirds of the existing data are based on observations and just a few prospective studies are available. In this regard, treatment is often empiric and because of the diversity of the treatment options, they should be tailored for each case separately.

Financial support and sponsorship

Conflicts of interest.

There are no conflicts of interest.

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